from unittest import TestCase, main

import numpy

from cogent3.maths.period import AutoCorrelation, Hybrid, Ipdft, ipdft
from cogent3.maths.stats.period import (
    SeqToSymbols,
    blockwise_bootstrap,
    chi_square,
    circular_indices,
    factorial,
    g_statistic,
    seq_to_symbols,
)


__author__ = "Hua Ying, Julien Epps and Gavin Huttley"
__copyright__ = "Copyright 2007-2020, The Cogent Project"
__credits__ = ["Julien Epps", "Hua Ying", "Gavin Huttley"]
__license__ = "BSD-3"
__version__ = "2020.12.21a"
__maintainer__ = "Gavin Huttley"
__email__ = "Gavin.Huttley@anu.edu.au"
__status__ = "Production"

from numpy.testing import assert_allclose, assert_equal


class TestPeriodStat(TestCase):
    def setUp(self):
        x = [
            1,
            0,
            1,
            0,
            1,
            0,
            0,
            0,
            0,
            1,
            1,
            0,
            0,
            0,
            1,
            0,
            1,
            0,
            0,
            1,
            0,
            1,
            0,
            0,
            1,
            0,
            0,
            0,
            0,
            1,
            1,
            1,
            0,
            1,
            0,
            0,
            0,
            0,
            1,
            0,
            1,
            1,
            1,
            1,
            0,
            0,
            0,
            1,
            1,
            0,
            1,
            1,
            1,
            0,
            0,
            0,
            1,
            1,
            1,
            1,
            1,
            1,
            1,
            0,
            0,
            1,
            0,
            0,
            1,
            0,
            0,
            0,
            0,
            1,
            0,
            1,
            1,
            1,
            1,
            1,
            1,
            0,
            0,
            1,
            1,
            1,
            0,
            0,
            0,
            0,
            1,
            1,
            0,
            0,
            0,
            0,
            1,
            1,
            0,
            1,
            0,
            1,
            1,
            0,
            1,
            0,
            0,
            0,
            1,
            0,
            0,
            0,
            1,
            0,
            0,
            0,
            0,
            1,
            1,
            1,
            0,
            1,
            0,
            1,
            0,
            1,
            1,
            1,
            0,
            0,
            1,
            1,
            0,
            1,
            0,
            1,
            0,
            0,
            0,
            1,
            0,
            0,
            0,
            0,
            1,
            1,
            1,
            0,
            0,
            0,
        ]
        self.x = numpy.array(x)
        self.sig = numpy.array(self.x, numpy.float64)
        self.motifs = ["AA", "TT", "TA"]

    def test_chi_square(self):
        D, cs_p_val = chi_square(self.x, 10)
        self.assertEqual("%.4f" % D, "0.4786")
        self.assertEqual("%.4f" % cs_p_val, "0.4891")

    def test_factorial(self):
        self.assertEqual(factorial(1), 1)
        self.assertEqual(factorial(4), 24)
        self.assertEqual(factorial(0), 1)

    def test_g_statitic(self):
        """calc g-stat correctly"""
        X, periods = ipdft(self.sig, llim=2, ulim=39)
        g_obs, p_val = g_statistic(X)
        assert_allclose(p_val, 0.9997, rtol=1e-3)
        assert_allclose(g_obs, 0.0577, rtol=1e-3)

    def test_circular_indices(self):
        v = list(range(10))
        self.assertEqual(circular_indices(v, 8, 10, 4), [8, 9, 0, 1])
        self.assertEqual(circular_indices(v, 9, 10, 4), [9, 0, 1, 2])
        self.assertEqual(circular_indices(v, 4, 10, 4), [4, 5, 6, 7])

    def test_seq_to_symbol(self):
        """both py and pyx seq_to_symbol versions correctly convert a sequence"""
        motifs = [b"AA", b"AT", b"TT"]
        symbols = seq_to_symbols(b"AATGGTTA", motifs, 2)
        assert_equal(symbols, numpy.array([1, 1, 0, 0, 0, 1, 0, 0]))
        symbols = seq_to_symbols(b"AAGATT", motifs, 2, numpy.zeros(6, numpy.uint8))
        assert_equal(symbols, numpy.array([1, 0, 0, 1, 1, 0]))

    def test_seq_to_symbol_factory(self):
        """checks factory function for conversion works"""
        motifs = ["AA", "AT", "TT"]
        seq_to_symbols = SeqToSymbols(motifs)
        got = seq_to_symbols("AATGGTTA")
        assert_equal(got, numpy.array([1, 1, 0, 0, 0, 1, 0, 0]))
        got = seq_to_symbols("AAGATT")
        assert_equal(got, numpy.array([1, 0, 0, 1, 1, 0], numpy.uint8))

    def test_permutation(self):
        s = (
            "ATCGTTGGGACCGGTTCAAGTTTTGGAACTCGCAAGGGGTGAATGGTCTTCGTCTAACGCTGG"
            "GGAACCCTGAATCGTTGTAACGCTGGGGTCTTTAACCGTTCTAATTTAACGCTGGGGGGTTCT"
            "AATTTTTAACCGCGGAATTGCGTC"
        )
        seq_to_symbol = SeqToSymbols(self.motifs, length=len(s))
        hybrid_calc = Hybrid(len(s), llim=2, period=4)
        ipdft_calc = Ipdft(len(s), llim=2, period=4)
        stat, p = blockwise_bootstrap(
            s, hybrid_calc, block_size=10, num_reps=1000, seq_to_symbols=seq_to_symbol
        )
        stat, p = blockwise_bootstrap(
            s, ipdft_calc, block_size=10, num_reps=1000, seq_to_symbols=seq_to_symbol
        )

    def test_permutation_all(self):
        """performs permutation test of Hybrid, but considers all stats"""
        s = (
            "ATCGTTGGGACCGGTTCAAGTTTTGGAACTCGCAAGGGGTGAATGGTCTTCGTCTAACGCTGG"
            "GGAACCCTGAATCGTTGTAACGCTGGGGTCTTTAACCGTTCTAATTTAACGCTGGGGGGTTCT"
            "AATTTTTAACCGCGGAATTGCGTC"
        )
        seq_to_symbol = SeqToSymbols(self.motifs, length=len(s))
        hybrid_calc = Hybrid(len(s), period=4, return_all=True)
        stat, p = blockwise_bootstrap(
            s, hybrid_calc, block_size=10, num_reps=1000, seq_to_symbols=seq_to_symbol
        )
        # print 's=%s; p=%s' % (stat, p)

    def test_get_num_stats(self):
        """calculators should return correct num stats"""
        hybrid_calc = Hybrid(150, llim=2, period=4)
        ipdft_calc = Ipdft(150, llim=2, period=4)
        autocorr_calc = AutoCorrelation(150, llim=2, period=4)
        self.assertEqual(hybrid_calc.getNumStats(), 1)
        self.assertEqual(ipdft_calc.getNumStats(), 1)
        self.assertEqual(autocorr_calc.getNumStats(), 1)
        hybrid_calc = Hybrid(150, llim=2, period=4, return_all=True)
        self.assertEqual(hybrid_calc.getNumStats(), 3)

    def test_permutation_skips(self):
        """permutation test correctly handles data without symbols"""
        s = "N" * 150
        seq_to_symbol = SeqToSymbols(self.motifs, length=len(s))
        ipdft_calc = Ipdft(len(s), llim=2, period=4)
        stat, p = blockwise_bootstrap(
            s,
            ipdft_calc,
            block_size=10,
            num_reps=1000,
            seq_to_symbols=seq_to_symbol,
            num_stats=1,
        )
        self.assertEqual(stat, 0.0)
        self.assertEqual(p, 1.0)


if __name__ == "__main__":
    main()
